| Groep A | ||
|---|---|---|
| Anzhi Makhachkala | 2-0 | BSC Young Boys |
| Liverpool | 2-3 | Udinese |
| Groep B | ||
| Atlético Madrid | 1-0 | Viktoria Plzen |
| Académica Coimbra | 1-1 | Hapoel Tel Aviv |
| Groep C | ||
| Borussia Mönchengladbach | 2-4 | Fenerbahçe |
| Olympique Marseille | 5-1 | AEL Limassol |
| Groep D | ||
| Club Brugge | 2-0 | CS Marítimo |
| Newcastle United | 3-0 | Girondins Bordeaux |
| Groep E | ||
| Molde FK | 2-0 | VfB Stuttgart |
| Steaua Boekarest | 1-0 | FC Kopenhagen |
| Groep F | ||
| PSV | 3-0 | Napoli |
| AIK | 2-3 | Dnipro Dnipropetrovsk |
| Groep G | ||
| Videoton FC | 3-0 | Sporting CP |
| FC Basel | 2-2 | Racing Genk |
| Groep H | ||
| Rubin Kazan | 2-0 | Partizan Belgrado |
| Neftchi Baku | 1-3 | Internazionale |
| Groep I | ||
| Hapoel Ironi Kiryat Shmona | 3-4 | Olympique Lyon |
| Sparta Praag | 3-1 | Athletic Bilbao |
| Groep J | ||
| Lazio | 1-0 | NK Maribor |
| Panathinaikos | 1-1 | Tottenham Hotspur |
| Groep K | ||
| Metallist Charkov | 2-0 | Rapid Wien |
| Rosenborg BK | 0-1 | Bayer Leverkusen |
| Groep L | ||
| Helsingborgs IF | 2-2 | FC Twente |
| Hannover 96 | 2-1 | Levante UD |