| AZ | 0-5 | Anzhi Makhachkala |
| APOEL Nicosia | 1-3 | Neftchi Baku |
| Newcastle United | 1-0 | Atromitos Athinon |
| Partizan Belgrado | 1-0 | Tromsø IL |
| Internazionale | 2-2 | FC Vaslui |
| Liverpool | 1-1 | Heart of Midlothian |
| HJK Helsinki | 3-3 | Athletic Bilbao |
| Dila Gori | 0-2 | CS MarÃtimo |
| sc Heerenveen | 1-2 | Molde FK |
| Club Brugge | 4-1 | Debreceni VSC |
| Olympique Marseille | 0-0 | Sheriff Tiraspol |
| Videoton FC |
0-0
(pen.: 4-2) |
Trabzonspor |
| BSC Young Boys | 0-2 | FC Midtjylland |
| Hannover 96 | 5-1 | Slask Wroclaw |
| Metallist Charkov | 2-1 | Dinamo Boekarest |
| Sporting CP | 5-0 | AC Horsens |
| Hapoel Tel Aviv | 4-0 | F91 Dudelange |
| Sparta Praag | 2-0 | Feyenoord |
| Levante UD | 1-0 | Motherwell |
| Girondins Bordeaux | 3-2 | Rode Ster Belgrado |
| Viktoria Plzen | 1-0 | Lokeren |
| Lazio | 3-1 | Mura 05 |
| CSKA Moskou | 0-2 | AIK |
| Rosenborg BK | 2-1 | Legia Warschau |
| FC Twente |
4-1
(n.v.) |
Bursaspor |
| Steaua Boekarest | 3-0 | Ekranas Panevezys |
| Dnipro Dnipropetrovsk | 4-2 | Slovan Liberec |
| Dinamo Moskou | 1-1 | VfB Stuttgart |
| Rapid Wien | 3-0 | PAOK Saloniki |
| Racing Genk | 2-0 | FC Luzern |
| PSV | 9-0 | Zeta |